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Not Rejuran or Juvelook

WELLS Dermatology CLINIC / WELLS美容皮膚科 · 웰스피부과 본원 블로그 · January 6, 2026

​ Hello. I’m Ryu Ho-seop, the head doctor of Wells Dermatology Clinic, with 22 years of experience as a dermatologist. ​ ​ When I consult with patients about skin boosters in the c...

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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.

Clinic: WELLS Dermatology CLINIC / WELLS美容皮膚科

Original post date: January 6, 2026

Translated at: April 25, 2026 at 6:18 AM

Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.

Not Rejuran or Juvelook image 1

Hello.

I’m Ryu Ho-seop, the head doctor of Wells Dermatology Clinic, with 22 years of experience as a dermatologist.

When I consult with patients about skin boosters in the clinic, many people feel confused because there are so many types of skin boosters.

"Doctor, how is it different from Rejuran?"

"Will it make my face plump like filler? Are there any side effects?"

Today, I’d like to talk about one of the many skin boosters, LITUO, which has been drawing the most attention recently.

"What if we used human collagen as it is?"

Starting from this question, I’ll explain how LITUO differs from existing procedures and who may need it.

Table of Contents

  1. Salmon (Rejuran) vs. human (LITUO): what’s different?

  2. Somewhere between filler and Rejuran

  3. Perfect for sensitive areas like under-eye hollows and eyelids!

  4. Duration and a great combination (feat. Thermage)

Not Rejuran or Juvelook image 2

  1. Salmon (Rejuran) vs. human (LITUO): what’s different?

If I had to define LITUO in one phrase, it would be a "real collagen booster."

The Rejuran we commonly know injects an ingredient (PN) extracted from salmon.

This ingredient stimulates the cells in the skin and sends a signal that says, "Produce collagen!" In other words, it is an indirect inducer.

LITUO is different.

It is made by turning ECM (extracellular matrix, including collagen) extracted from human tissue into powder and directly putting it into the skin.

Simply put,

if Rejuran is like "spreading fertilizer so collagen can grow,"

LITUO is like "planting a strong, fully grown tree (collagen) directly."

So, in addition to the effect of volume filling immediately after injection, you can expect combined effects such as pore reduction, increased hydration, and improvement in fine wrinkles.

Not Rejuran or Juvelook image 3

  1. Somewhere between filler and Rejuran

LITUO’s position is very clear.

It is right in the middle of "filler and Rejuran."

  • Filler: It definitely adds volume, but you may worry about a foreign-body sensation or an unnatural look.

  • Sculptra/Juvelook: They stimulate collagen production, but people sometimes hesitate because of the rare risk of a "nodule" side effect.

LITUO solves these concerns.

Because it is human-derived, it causes less foreign-body sensation, and unlike Sculptra, it carries almost no burden of having nodules that require surgical removal.

If you want the effect of naturally filling in sunken areas (the advantage of filler) while also improving skin texture (the advantage of a skin booster), LITUO may be the answer.

Not Rejuran or Juvelook image 4

  1. Perfect for sensitive areas like under-eye hollows and eyelids!

There is one area where I strongly recommend LITUO.

That is the eye area.

When the area under the eyes or above the eyes (eyelids) becomes deeply sunken, a person looks tired and older.

However, this area has thin skin, so if filler is injected incorrectly, it can become bumpy (Tyndall effect), and because particle-based boosters like Juvelook carry a risk of nodules, the procedure is very delicate.

At such times, LITUO becomes an excellent alternative.

Because its fine collagen particles spread evenly even through thin skin layers,

it can fill dark circles under the eyes or sunken eyelids very naturally and safely.

Not Rejuran or Juvelook image 5

  1. Duration and a great combination (feat. Thermage)

Usually, Rejuran lasts about 2 to 3 months,

but LITUO’s effects last for about 6 months with a single treatment.

This is because human-derived collagen goes through a process of being gradually absorbed and regenerated.

If you want a stronger effect, I recommend combining it with Thermage.

  • Thermage: wakes up existing collagen with radiofrequency heat,

  • LITUO: adds plenty of new collagen material?

Together, they create tremendous synergy, leading to maximized firmness and volume.

Not Rejuran or Juvelook image 6

In closing

LITUO is a safe, human-derived collagen that has been verified over many years.

① For those who dislike the unnatural look of fillers

② For those worried about nodule side effects from Sculptra/Juvelook

③ For those concerned about aging in sensitive areas such as under-eye wrinkles and neck wrinkles

For these people, LITUO will be the safest and most effective choice.

If you want to give your skin real collagen, consult with a specialist and try LITUO.

Thank you for reading this long post.

This has been chief director Ryu Ho-seop.

[Articles worth reading together]

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Best 2. I’ll tell you the routine for creating egg-shell skin.

Best 3. If you felt that Ultherapy alone was 2% lacking

Wells Dermatology Clinic main phone number: 02 - 542 - 2372
Weekdays 10:00 ~ 20:00
Saturday 10:00 ~ 17:00
Lunch break 13:00 ~ 14:00
Closed on Sundays and public holidays

This post was written directly by Wells Dermatology Clinic and complies with all laws and regulations regarding medical advertising, other than Article 56, Paragraph 1 of the Medical Service Act.

Please note that all surgeries and procedures may involve side effects depending on the individual, so please make sure to receive sufficient medical guidance from the medical staff before carefully deciding whether to undergo the procedure.

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