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Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox)

WELLS Dermatology CLINIC / WELLS美容皮膚科 · 웰스피부과 본원 블로그 · January 19, 2026

​ Hello. ​ I am Yoo Hyo-seob, a dermatologist with 22 years of experience. ​ ​ "Is Rejuran alone enough?" ​ "Is it better to get it together with Botox?" ​ ​ When consulting about...

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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.

Clinic: WELLS Dermatology CLINIC / WELLS美容皮膚科

Original post date: January 19, 2026

Translated at: April 25, 2026 at 6:18 AM

Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 1

Hello.

I am Yoo Hyo-seob, a dermatologist with 22 years of experience.

"Is Rejuran alone enough?"

"Is it better to get it together with Botox?"

When consulting about skin boosters in the clinic, I get these questions very often.

Today, I’d like to talk about a representative procedure that can help address the concerns of women in their 30s, 40s, and 50s who are highly interested in skin aging,

Rejuran and Botox.

Table of Contents

  1. What is Rejuran? The flagship skin booster

  2. What is skin Botox (dermotoxin)? Botox injected into the skin layer

  3. Rejuran Tox: Two effects from one procedure

  4. How to use Rejuran and Botox by age group

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 2

  1. What is Rejuran? The flagship skin booster

Rejuran is the most well-known product among skin booster procedures that administer specific substances into the dermis layer of the skin.

The ingredients in Rejuran can be broadly divided into two types.

First, growth factors.

Growth factors help the skin produce collagen, which supports anti-aging.

Second, moisturizing factors.

Moisturizing factors improve the skin’s ability to attract and retain water, helping to relieve symptoms such as inner dryness and tightness.

Rejuran can be received conveniently in under 10 minutes without anesthesia or a long procedure time,

and because the cost is relatively not expensive, it is also one of the procedures most often recommended to people trying skin treatments for the first time.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 3 2. What is skin Botox (dermotoxin)? Botox injected into the skin layer

As you know, Botox is used by injecting it into muscles for the purpose of treating and preventing wrinkles.

However, there is a method of injecting Botox into the skin layer like Rejuran, and this is called skin Botox or dermotoxin.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 4

The action of skin Botox is different from regular Botox.

First, it can treat fine wrinkles.

Second, it can reduce pores by paralyzing the muscle called the arrector pili muscle.

Third, it can also help improve redness by suppressing the small nerves distributed in blood vessels.

Regular Botox is injected deeply into the muscle layer to paralyze the muscle, while skin Botox dilutes the drug and injects it into the dermis layer of the skin.

Therefore, because it does not affect normal muscle movement, it can be used on the entire face without issue,

and you can experience effects such as improved fine wrinkles, reduced pores, and improved redness without the side effect of a stiff facial expression.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 5 3. Rejuran Tox: Two effects from one procedure

Both Rejuran and skin Botox are procedures that inject drugs into the dermis layer of the skin.

So if Rejuran and Botox are mixed beforehand and injected before the procedure, you can get two effects at the same time from one treatment.

This is the Rejuran Tox procedure that has recently been getting much attention from many people.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 6

To summarize the advantages of Rejuran Tox:

While increasing skin elasticity and moisture with Rejuran’s growth factors and moisturizing factors,

you can also obtain the fine wrinkle improvement, pore reduction, and redness improvement effects of skin Botox at the same time.

Above all, being able to see two effects from one procedure and one instance of pain makes it an efficient choice in terms of both time and cost. Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 7 4. How to use Rejuran and Botox by age group

So, how should Rejuran and Botox be used depending on age?

▶ 30s

Basically, for Botox that paralyzes the muscles of the forehead, glabella, and eye area, I recommend that all people in their 30s receive it at least once a year.

If you do not receive it consistently from a younger age and then develop fixed wrinkles in your 50s or 60s, the effect of Botox is limited at that point.

Rejuran is a procedure I recommend to anyone, regardless of age.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 8

Whether you are in your 20s, 60s, or 70s, the skin can always become dry,

and because administering growth factors helps skin health and anti-aging, much like taking a restorative tonic for the body.

In your 30s, because wrinkles are not severe, if the cost is a concern, it is also fine to receive only Rejuran periodically.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 9

▶ 40s to 50s

As you move into your 40s and 50s, I definitely recommend getting the procedure as Rejuran Tox by mixing Rejuran and Botox.

This is because you can steadily maintain anti-aging effects along with wrinkle prevention.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 10

▶ 50s to 60s and older

Once you are in your 50s or 60s, there may actually be limits to Rejuran Tox alone.

In such cases, you may get better results by combining more effective and proven anti-aging procedures such as Thermage, Ulthera, and Sculptra.

Rejuran Procedure: Can It Improve Wrinkles When Combined with This? (The Effects of Rejuran Tox) image 11

In closing,

Rejuran is a representative skin booster that gives the skin moisture and elasticity,

and skin Botox is a procedure that improves fine wrinkles, pores, and redness.

Rejuran Tox, which mixes these two together, allows you to get two effects at the same time from one procedure,

making it an efficient anti-aging solution for busy modern people.

If you choose an appropriate combination of procedures according to your age and skin condition, you will be able to achieve more satisfying results.

Thank you for reading this long post.

This has been Yoo Hyo-seob, Chief Director.

[Articles worth reading together]

Best 1. Introduction

Best 2. I will explain Botox resistance, dosage, and frequency.

Best 3. What procedures slow down skin aging?

Wells Dermatology Main Phone Number (click the number below to connect)
02 - 542 - 2372
Clinic Hours
Weekdays 10:00 ~ 20:00
Saturday 10:00 ~ 17:00
Lunch Break 13:00 ~ 14:00
Closed on Sundays and public holidays

This post was written directly by Wells Dermatology Clinic and complies with all laws regarding medical advertising other than Article 56, Paragraph 1 of the Medical Service Act.

All surgeries and procedures may be accompanied by side effects depending on the individual, so please receive sufficient guidance from the medical staff and carefully decide whether to proceed with the procedure.

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