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What is the difference between Wegovy and Mounjaro?
Hello,
I’m Hyunju Seong, director of Cheongdam OK Clinic.

| ▶ Full member of the Korean Society of Aesthetic Plastic Surgery (KACS) |
|---|
| ▶ Full member of the Korean Society for the Study of Obesity (KSSO) |
| ▶ Full member of the Korean Academy of Obesity, Cosmetic and Body Contouring (KAAM) |
| ▶ Full member of the Korean Society of Liposuction Surgery (KSSL) |
| ▶ Full member of the Korean Society of Aesthetic Surgery (KSAS) |
Recently, Wegovy and Mounjaro have been
mentioned a lot as weight management treatments.

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What both medications have in common is that they are
injections made based on hormones involved in appetite control
and metabolism.
They differ from existing simple appetite suppressants
in that they use the body’s hormone action.

When choosing a medication for weight management purposes, it is important to consider not only the amount of weight loss,
but also the individual’s health status and metabolic condition.
Wegovy’s mechanism and expected changes
Wegovy is a medication administered once a week.
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It enhances the action of the GLP-1 hormone, which affects appetite control,
and is characterized by helping people feel full for longer.

Because it works in a way that naturally reduces food intake,
a certain amount of weight loss may appear over a period of time.
In research results, when used together with lifestyle improvements,
a certain average level of weight loss has been reported.
The director’s actual 6-month Wegovy experience (left) before, (right) after
However, not everyone experiences the same changes,
and results vary depending on an individual’s lifestyle habits and metabolic condition.
Mounjaro characteristics and dosage stages
Mounjaro is also a once-weekly injectable,
and is known as a medication that acts on two hormonal pathways at the same time.
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It is introduced as being characterized by the simultaneous use of GLP-1 and GIP action.
Some studies have reported cases of relatively greater weight loss with Mounjaro use.

However, responses differ from person to person, and medications for weight management often only lead to meaningful changes when combined with lifestyle control.
Comparison of Wegovy and Mounjaro
Both medications are used as weight management treatments, but they differ in mechanism and dosage structure.
| Category | Wegovy | Mounjaro |
|---|
| Mechanism of action | GLP-1 hormone action | GLP-1 + GIP action |
| Administration | Once-weekly injection | Once-weekly injection |
| Starting dose | 0.25mg | 2.5mg |
| Dose escalation | Gradual increase | Gradual increase |
| Main effect | Reduced appetite, increased satiety | Appetite control + metabolic action |
| Reported weight loss | Varies by person | Varies by person |
| Common reactions | Nausea, digestive discomfort | Nausea, gastrointestinal discomfort |
Both medications may cause gastrointestinal
symptoms during the initial stage of use.

Commonly reported reactions include nausea, stomach discomfort,
and changes in appetite.
These reactions may ease during the process of gradually increasing the dose, but this varies from person to person.
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The important point is that results are not determined by weight management medication alone.
Adjusting eating habits and lifestyle patterns together can affect long-term results.
Thank you for reading this long post today. ^^
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