[Dr. Bellvue Column 71.] Comparison of Lizne and Rejuran

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[Dr. Bellvue Column 71.] Comparison of Lizne and Rejuran image 1

Comparison of Lizne and Rejuran

You've probably all heard the name 'Rejuran' at least once—it is a well-known skin booster in dermatology. It is highly effective for replenishing moisture in dry skin and improving skin condition. A similar skin booster called 'Lizne' has also been gaining popularity recently. Both Lizne and Rejuran are skin booster products developed and produced in Korea, and they have also received a strong response from overseas users.

Among the many skin boosters available, Lizne is often compared with Rejuran because they use the same ingredient and have similar names. Some people even refer to Lizne, the later entrant, as a 'cheaper version of Rejuran.' Both products share the common benefits of promoting skin regeneration and helping collagen production, but there are also a few differences. Today, let's take a brief look at them.

[Dr. Bellvue Column 71.] Comparison of Lizne and Rejuran image 2 Lizne is classified as a Class 4 medical device released by a domestic pharmaceutical company called 'Yuventa Healthcare.'

Getting to Know Lizne (LIZNE)

The main ingredient in Lizne is 'polynucleotide (PN),' the same as in Rejuran. (Manufacturer: Yuventa Healthcare, Korea) Polynucleotide (PN) is an ingredient extracted from salmon testes and is similar to human DNA, making it a substance that can be used without a foreign-body sensation. There is also a substance called PDRN, extracted from salmon reproductive cells, which is mainly used in salmon injections, PDRN injections, and baby skin booster procedures. The names are similar, so it can be confusing. PN is a DNA fraction with a longer nucleic acid chain than PDRN and is approved as a Class 4 medical device material. PN and PDRN are both DNA fragments extracted from salmon DNA and are similar ingredients that show skin regeneration and anti-inflammatory effects, but there are a few important differences, which we have organized in the table below.

	PN (Polynucleotide)	PDRN (Polydeoxyribonucleotide)
Definition	PN is a long-chain DNA fragment with a larger molecular weight than PDRN.	PDRN is a fragmented DNA piece with a smaller molecular weight than PN.
Features	It tends to remain in the skin longer, so a more sustained effect can be expected. It has a stronger ability to attract moisture, which may be more beneficial for skin hydration and a dewy glow. It is mainly used as a raw material for medical devices (for example, Rejuran). It is often classified as a Class 4 medical device. Class 4 corresponds to medical devices with a high potential risk to the human body and undergoes strict safety and efficacy evaluation. PN products used for tissue restoration biomaterials and similar purposes include Rejuran and Lizne, which have been approved as Class 4 medical devices. Because of its larger molecular weight, the embossing effect (unevenness on the skin surface) after injection may last longer than with PDRN.	It tends to be absorbed into the skin more quickly. Wound healing and tissue regeneration are the main characteristics of PDRN. It is mainly used as a pharmaceutical or cosmetic ingredient. It is often used as a pharmaceutical product (for example, some wound treatments). There are also PDRN products classified as Class 4 medical devices. Because of its smaller molecular weight, it is also used as a cosmetic ingredient, and in that case it does not fall under medical device classification. Compared with PN, it has the advantage of less embossing and faster recovery.

[Dr. Bellvue Column 71.] Comparison of Lizne and Rejuran image 3 Embossing effect

The key difference is, first, molecular weight. PN has a larger molecular weight than PDRN. Their range of applications is also slightly different. PN tends to be used mainly in medical devices, especially as a biomaterial for skin regeneration and tissue restoration, whereas PDRN is used across a broader range, including pharmaceuticals, medical devices, and cosmetics. Most skin boosters with PN as the main ingredient are Class 4 medical devices, while PDRN may be classified as either a pharmaceutical or a Class 4 medical device depending on the intended use and formulation. However, as shown in the table above, it is difficult to say that either PN or PDRN is simply 'better.' In other words, the more suitable ingredient depends on the purpose and application area.

☆ If you want skin regeneration, wound healing, quick absorption, and fast recovery -> PDRN may be more suitable.

☆ If you want skin hydration, elasticity, long-lasting effects, and a dewy glow -> PN may be more suitable.

◆ Media reports related to Lizne

Lizne is a tissue restoration biomaterial made from the biocompatible substance polynucleotide (PN, Polynucleotide Sodium) as its raw material, and it is a product approved as a medical device by the Ministry of Food and Drug Safety after clinical trials were conducted on about 250 Koreans.

The PN used as the main raw material for Lizne is produced at a state-of-the-art smart aquaculture facility in Goheung, Jeollanam-do. Through a seawater acclimation method for salmonid fish, land-based aquaculture was successfully achieved, and a patent was obtained for a high-purity DNA manufacturing method. By producing and managing every process domestically, from raw material extraction to production, the company secured top-level quality.

Source: https://www.medipana.com/article/view.php?news_idx=321612&sch_cate=F

To summarize Lizne's features...

Compared with Rejuran, it has smaller particles and a thinner texture. During the procedure, pain may be less, and bruising, swelling, and embossing (unevenness on the skin surface) may occur less.
It is known to be relatively suitable for use on thin skin such as around the eyes and mouth with less burden.
Another advantage is that it is relatively less expensive than Rejuran.

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Getting to Know Rejuran (Rejuran)

Its main ingredient is also polynucleotide (PN). It is a specific DNA fragment extracted from salmon DNA and shows skin regeneration and anti-inflammatory effects. (Manufacturer: PharmaResearch, Korea) Rejuran entered the market much earlier than Lizne, built up recognition over a long period of time, and helped introduce the concept of a 'skin booster' to the public. This first-mover advantage and brand power can be reflected in the price. It is similar to how a well-known brand product may be sold at a higher price even when its function is similar. Now that Rejuran's technology and reputation are expanding globally, they cannot be overlooked.

◆ Media reports related to Rejuran

Rejuran is known to improve fine lines on the face and around the eyes, and to be excellent for reducing scars and improving skin elasticity. Rejuran and Conjuran were made using PharmaResearch's proprietary DNA optimization technology (DOT), and they contain polynucleotide sodium (NP), a regenerative substance extracted from salmon DNA, which promotes collagen and elastin production.

Earlier, PharmaResearch obtained EU Medical Device Regulation (MDR) certification at the end of last year to enter the European market.

Currently, China accounts for more than half of PharmaResearch Rejuran's total export volume, and sales in Asia, especially in Vietnam and Thailand, account for more than 70%. PharmaResearch is focusing on market diversification to address this regional concentration and increase sales.

Founded in 2001, PharmaResearch had mainly focused on imported pharmaceuticals such as Zadakine, an immune enhancer, but in 2018 it acquired the filler business division of Estea, a subsidiary of Amorepacific Group, and began developing its own pharmaceuticals. In 2014, it launched Rejuran, a product that helps skin regeneration using DNA extracted from salmon, and has become prominent in the beauty field.

Source: M Today (https://www.autodaily.co.kr)

To summarize Rejuran's features...

As a leader in Korea's skin booster market, it has accumulated a long period of clinical experience and data.
It is effective for improving overall skin condition, including skin regeneration, fine line improvement, enhanced elasticity, improved moisture, and pore reduction.
Rejuran tends to have a higher viscosity than Lizne, so there may be some pain during the procedure, and the embossing effect may last for several days. (Lizne is thinner and has lower viscosity than Rejuran, and this difference in formulation may also affect the production process and lower costs.)
Rejuran has a wide lineup (Rejuran Healer, Rejuran I, Rejuran HB, etc.), giving users a broad range of options depending on the area or purpose.

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Lizne vs. Rejuran: Which one should you choose?

Both products use PN as their main ingredient and are skin boosters that can be expected to have skin regeneration effects. Dr. Bellvue will clearly present the 기준 so that you can make a better choice by considering the formulation, treatment cost, whether there is enough time for recovery after the procedure, and your own pain sensitivity from multiple angles. If you...

Are sensitive to pain or embossing, prefer a more natural result with less visible sign of treatment, and want a reasonable price -> Lizne may be a better choice.
Prefer a powerful effect that has been proven over a long period of time, want a variety of product lines, and are looking for overall skin condition improvement -> Rejuran is worth considering more deeply.

That’s all for today.

Thank you for reading.

This has been Dr. Bellvue~!

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