Comparing the 3 Major Skin Boosters [Rejuran, Juvelook, Lituo]

Hello?

Bellevue Clinic, Beauty for everyone.

We’re back with another greeting today.

“Which skin booster is best suited for me?” This is a common concern for many people when they visit a dermatology clinic for a consultation. It may hurt, but people say the results are very good. Since it is not cheap, we understand the desire to see results that match — or exceed — the investment. Today’s post is a complete guide to the three skin boosters that are mentioned most often and are widely popular: Rejuran vs. Juvelook vs. Lituo.

From Rejuran to Juvelook, and now the recently emerging Lituo. As the options continue to increase, patients’ worries deepen as well. Decision paralysis(?) tends to follow. In fact, there is no such thing as “the best skin booster.” What matters first is figuring out whether your skin currently needs stimulation or whether it lacks the actual building material. Let’s compare what role each skin booster plays within the skin through easy-to-understand analogies.

Rejuran (PN) - Gives a signal for regeneration

Rejuran Healer’s main ingredient is PN (Polynucleotide), extracted from salmon DNA. It plays the role of delivering a strong repair message to skin cells. Once PN enters the skin, it acts like a signal flare, telling damaged cells, “Start repairs immediately!” In other words, rather than trying to directly fill the skin, this skin booster focuses on boosting the skin’s own regenerative ability. Rejuran is suitable for skin with a weakened oil-water balance and increased sensitivity, skin that has become red from irritation, and skin with a thin barrier that easily develops problems. It is especially helpful when used along with treatment after the skin has been irritated by other dermatologic procedures, or when regeneration is needed afterward, because recovery is very fast. Like a restorative tonic taken during recovery, it is excellent for building the skin’s basic strength, but the procedure can be somewhat painful and embossing may appear.

Juvelook (PDLLA) - Promotes collagen production

Juvelook is a skin booster that combines PDLLA (a high-molecular-weight PLA) with hyaluronic acid, and it is often described as the representative product for “autologous collagen production.” It is relatively affordable, and because it comes in both skin and volume types, it is used in a wide range of cases. The tiny particles in Juvelook gradually break down inside the skin and continuously stimulate fibroblasts. Like planting a seed that sprouts over time, it is a catalyst that helps your body produce collagen on its own over the weeks following treatment. It is a good skin booster for people who normally have enlarged pores and rough skin texture, are concerned about fine lines, or feel that their overall volume is lacking. It gives a much more natural-looking volume than fillers and the effect lasts a long time, but because the results are not immediately visible, patience is needed until collagen forms.

Lituo (atelocollagen) - Fills the dermis

The newest skin booster, Lituo, uses atelocollagen as its main ingredient. This is a highly purified form of collagen from which the telopeptides that can trigger immune rejection have been precisely removed. It is somewhat different in nature from the skin boosters above. It feels closer to a filler, in some ways.

Lituo is a skin booster that focuses on supplementing the dermal structural components themselves (a kind of dermal graft) rather than sending signals or inducing a response. In other words, it directly injects type I collagen, which makes up 90% of the dermis. Rather than ordering workers to start building and waiting, you could say it is like bringing truckloads of the bricks needed for the construction site and stacking them right away. There are dozens of types of collagen in the body, but atelocollagen skin boosters (such as Lituo) mainly use type I collagen. More than 90% of the dermis in our skin is made up of type I collagen. When the dermis becomes thinner due to aging, this method directly supplies the most needed ingredient in a very similar form.

So, Lituo is a skin booster that acts as a kind of scaffold. It serves as a physical structure within the skin and firmly supports loosened skin tissue. By directly injecting type I collagen into the dermis, which has thinned with age, it immediately compensates for the weakened skin structure. Rather than waiting for cells to produce collagen, it replenishes lost dermal components as if grafting them in, making it excellent for restoring skin thickness.

You may find the term atelocollagen unfamiliar. Here, “atelo” means that the telopeptide, the tail of collagen that causes immune reactions, has been removed. Telopeptide is the “tail” portion attached to both ends of the collagen molecule. “Telo-” comes from the Greek word for “end” or “termination.” “Atelo-” adds a negative meaning here, signifying “without an end (telo).” A typical collagen molecule has a triple-helix structure made of three intertwined strands. At both ends of this helix are non-helical regions called telopeptides. These telopeptides are the main cause of immune rejection reactions in the human body, such as allergies and inflammation. If animal-derived collagen is injected into the human body as is, our body recognizes this tail portion as a foreign invader and attacks it.

In other words, the name atelocollagen itself contains the meaning “collagen from which the tail that causes immune reactions (telopeptide) has been removed by enzymatic processing.” Thanks to this, even skin that is sensitive to external substances can safely experience effects similar to a “dermal graft” without worrying about allergies. We strongly recommend Lituo for those whose skin has become paper-thin due to aging, those whose elasticity has rapidly declined and started to sag, and those who gave up on Rejuran because of pain.

🔍 A quick skin booster comparison guide

Category	Rejuran (PN)	Juvelook (PDLLA)	Lituo (Atelocollagen)
Analogy	Signal flare (Start the repair!)	Catalyst (Let’s plant the seed!)	Actual material (Let’s stack the bricks!)
Core ingredient	Salmon-derived DNA fragments	Particles that induce autologous collagen	Pure medical-grade collagen
Main effect	Skin regeneration, barrier strengthening	Pore/skin texture improvement, volume formation	Dermal thickness recovery, elasticity
When you feel it	About 1 week later (texture improvement)	4–6 weeks later (volume)	Immediate to 2 weeks (firmness)

Which one should you choose?

★ If your skin is extremely sensitive and red, and calming it down is urgent? → Rejuran

★ If you have large pores and want smooth, porcelain-like skin texture? → Juvelook

★ If your skin is thin, lacks firmness, and you want an immediate feeling of tightness? → Lituo

In this way, each skin booster has a clearly defined role. Sometimes they can be used in combination for synergy, such as filling in the material with Lituo and then stimulating the skin with Juvelook. The most successful treatment begins with a diagnostic process through consultation with medical staff to determine exactly what your skin needs right now. Bellevue Clinic offers customized procedures optimized for each patient’s dermal condition through precise diagnosis. If you have more questions about Rejuran, Juvelook, or Lituo, or if you want to know which combination of treatments is right for your skin, feel free to contact us anytime. Bellevue will give you a clear answer. Thank you.

#BellevueClinic #Rejuran #Juvelook #Lituo #SkinBooster #GangnamSkinBooster #DermalGraftEffect #BestSkinBooster #SkinBoosterTypes #SkinBoosterRecommendation #JuvelookPores #BellevueClinic

If you are 고민ing about which procedure is more suitable for you, visit Bellevue Clinic and have a thorough consultation with our medical professionals. We will accurately diagnose your skin condition and suggest the most effective method.

“Specializing in skin diagnosis”

Bellevue Clinic

The Mark-Vu skin diagnostic test can check, all at once, various skin concerns that are difficult to identify with the naked eye, such as skin texture, pigmentation, pores, wrinkles, skin tone, dark circles, radiance, redness, melanin, sebum, and acne-causing bacteria.

At Bellevue, we scientifically analyze your skin based on this and make a final diagnosis of the procedures needed. Through detailed consultations, we will do our best to provide patients with the most effective treatments.

<Consultation & Directions>