A Comparison of Rejuran, Juvelook, and Re2O: Which Skin Booster Causes Less Bumpiness and Pain?

A Comparison of Rejuran, Juvelook, and Re2O: Which Skin Booster Causes Less Bumpiness and Pain?

Hello, this is Bellevue Clinic. Today, we are talking about skin boosters. There are now so many types available that choosing which one to receive can be quite confusing.

Skin boosters can be simply compared to highly concentrated supplements or tonics that help improve the skin’s basic condition. (Strictly speaking, supplements and tonics affect the entire body rather than only the skin, so the comparison is not perfectly exact. Please understand that this is simply an analogy used to make the concept easier to understand.) Skin boosters act only on the skin.

Skin Booster is a combination of the words “skin” and “booster.” It is a general term for procedures that directly inject active ingredients that help improve the skin barrier and support regeneration—such as hyaluronic acid, PN, PLLA, and exosomes—into the dermal layer of the skin. Unlike oral supplements, which act throughout the body, skin boosters work intensively on the targeted dermal layer, meaning their effects are limited to the skin.

The results and duration can vary depending on the nature of the ingredients and the response after injection—for example, whether the nourishing ingredient is an artificially synthesized regenerative material or an actual skin component, meaning tissue-derived from the human body. Strictly speaking, the leading skin boosters on the market are not “artificially synthesized regenerative materials” so much as ingredients extracted and purified through biotechnology. (For example, Rejuran contains PN extracted from salmon DNA, while Juvelook contains the lactic acid polymer PDLLA, obtained through microorganisms and other processes.) This is really the key point. Which skin booster is right for my skin? This is where the choice is determined.

The right skin booster can vary completely depending on the patient’s skin thickness, sensitivity, oil-moisture balance, and daily schedule—specifically, how much downtime they can accommodate while bumps or bruising remain after the procedure. Therefore, it is helpful to compare the characteristics of each ingredient and the responses after injection, including pain, downtime, and when the effects appear. Let’s compare the differences among three representative skin boosters frequently used in dermatology clinics: Rejuran, Juvelook, and Re2O, from several perspectives.

If you have been interested in skin boosters but

weren’t sure what options were available,

this will be useful information,

so please read to the end!

1. Glow Injection

Immediate hydration for dry skin

The key ingredient is hyaluronic acid (HA)

Glow injections directly introduce into the dermal layer an ingredient that draws in hundreds of times its own weight in water. Since the principle is similar to urgently supplying water from outside to a rice field with dried-up soil, you can feel immediate moisture and a dewy glow after the procedure. However, because the focus is on “temporary hydration” rather than fundamentally changing the cellular environment, the duration tends to be relatively short.

The HA used in glow injections is generally non-crosslinked HA, with no cross-linking or only very weak cross-linking. It has a strong ability to attract moisture, providing immediate radiance and hydration, but it is quickly broken down by enzymes in the skin, so its duration is short. It can be compared to a brief relationship that lasts only one to three months—enough time to make you excited before suddenly disappearing. It was nice, but a little disappointing.

2. Rejuran & Juvelook

Stimulating cellular regeneration

Rejuran (PN ingredient)

Juvelook (PDLLA + HA ingredients)

Rejuran (PN ingredient)

DNA fragments extracted from salmon are injected into the dermal layer. Rejuran is helpful for repairing a damaged skin barrier, strengthening the skin, and balancing oil and moisture. However, because of the properties of the ingredient, it is highly viscous and tends to be more painful during injection. In addition, as the particles are absorbed, the skin may become raised and bumpy for several days, a phenomenon known as “embossing.” Rejuran is like a stable boyfriend you have been dating for about a year. The early dating stage may involve some pain, but afterward he makes you feel comfortable and secure—perhaps like a caring tonic-like boyfriend. I’m not sure whether the analogy is appropriate, but I was trying to come up with something, haha!

When you hear that the duration is “one year,” you may misunderstand this to mean, “Does one treatment last for a year?” Rejuran is generally understood to provide a cumulative regenerative effect that gradually lasts for several months, and in some cases close to a year, when administered at least three times at intervals of three to four weeks. Please understand it not as “one treatment lasting one year,” but as “long-term skin improvement that can be maintained when the recommended treatment schedule is completed.”

Juvelook (PDLLA + HA ingredients)

Round, porous particles derived from lactic acid are injected. There are two versions: Skin and Volume. As these particles break down within the skin, they stimulate surrounding cells and promote the production of the skin’s own collagen. Through a “self-tissue regeneration” mechanism in which the breakdown of PDLLA particles attracts macrophages and stimulates fibroblasts to induce collagen production, Juvelook can help naturally improve elasticity and refine pores. However, the process of inserting it with fine needles or an injector involves some pain and requires a short recovery period.

Juvelook is like a male friend who gradually becomes part of your daily life and continually encourages and supports your growth and development—a mentor-like male friend, perhaps. That seems like a good way to put it. Unfortunately, after about one to one and a half years, the relationship naturally begins to drift apart. Juvelook also takes time for the particles to break down and collagen to build up, but one advantage is that its duration can be somewhat longer than Rejuran because of the newly formed tissue.

3. Re2O

Immediately supplementing the dermal structure

with human-derived allogeneic dermis

The key ingredient is acellular human dermal matrix (hADM)

Whereas conventional skin boosters “induce” cellular responses through external substances or artificial stimulation, Re2O takes an entirely different approach. It consists of allogeneic dermal tissue that has been safely stripped of cells and purely purified from actual human dermal tissue. It directly injects into the dermal layer a “genuine skin component” that perfectly corresponds to the extracellular matrix (ECM) structure—the core framework of our skin.

If Rejuran and Juvelook are “stimulators” that activate cells, Re2O is closer to a “structural replacer” that directly fills in the lost dermal environment. Rather than introducing a foreign substance to stimulate cells to work, it immediately supplements the genuine dermal components lost with age and helps remodel the cellular ecosystem in a healthier way. Comparing it to a relationship, could it be described as a soulmate who feels like a spiritual partner? Its duration is around one year, similar to existing skin boosters, but while you are together, it is a precious relationship that makes you feel younger and more vibrant. That is the kind of wonderful connection it is.

★ Why Bellevue Recommends Re2O to Beginners

Because it is derived from human tissue, it does not cause a foreign-body reaction or an excessive rejection response in the skin. In particular, the particles are refined to be extremely precise and fine, so the pressure required to insert them—the injection resistance—is low when using fine needles or precision injector equipment, resulting in significantly less pain. Compared with conventional injectables such as Rejuran, raised, bumpy marks are barely visible or settle very quickly. This welcome treatment has minimal downtime, allowing you to apply makeup immediately after the procedure and return to your daily activities.

Skin boosters are not procedures in which volume remains in place as it does with fillers; they are procedures that improve the environment of skin cells. Therefore, please remember that the effects tend to last longer with a cumulative course of at least three treatments rather than a single treatment. It is best to choose a skin booster according to your skin’s sensitivity, sensitivity to pain, and daily schedule. Of course, cost should also be considered, but this is the case when looking only at the results. Since you generally need around three treatments once you begin, and the results may last for more than a year, it is best to make a thoughtful and well-informed choice.

If you want to repair and strengthen your skin barrier even if it means tolerating needle marks, significant pain, and several days of embossed bumps, Rejuran or Juvelook can provide clear, tangible feedback. On the other hand, if you are very afraid of pain and want to fill your skin with “genuine skin components” to create a natural and refined glow without the downtime of having a bumpy face after treatment, Re2O skin booster is the answer.

A Comparison of Rejuran, Juvelook, and Re2O: Which Skin Booster Causes Less Bumpiness and Pain?

Restore your facial skin so that it becomes stronger, clearer, more hydrated, and firmer in the safest and most natural way. Bellevue Clinic at Gangnam Station will sincerely help protect your precious skin through a precise, one-on-one customized consultation and diagnosis. Thank you!

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The Mark-Vu skin diagnostic examination can identify various skin concerns at once that are difficult to detect with the naked eye, including skin texture, pigmentation, pores, wrinkles, skin tone, dark circles, radiance, redness, melanin, sebum, and acne-causing bacteria.

At Bellevue, we scientifically analyze your skin based on these findings and make a final diagnosis of the treatments you need. Through detailed consultations, we will do our best to provide the most effective treatment for each patient.

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