Hello, I’m Dr. Jo Wonjin, and I’ve been seeing patients for 10 years.

Does Lituo also have a risk of nodules like Juvelook?
To give you the conclusion first, Lituo is a procedure in which the likelihood of nodules forming is very low because of how it works.
Even so, why do people worry about this, and how can we minimize the risk of nodules?
I’ll talk about this under the topic, How to Prevent Lituo Nodules in Hongdae.

Table of Contents
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The principle and effects of Lituo, and why nodules form
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Two ways to prevent Lituo nodules
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Lituo cannula or manual injection: which should you choose?
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Frequently asked questions about Lituo (Q&A)
- The principle and effects of Lituo, and why nodules form
Many people often confuse Hongdae Lituo with procedures such as Juvelook.
Juvelook acts like a kind of seed that induces collagen production within the skin.
At this time, if the product clumps in a certain area, collagen can be produced excessively and hard nodules can form.

By contrast, Lituo is a method that directly supplies collagen itself, which is a component of our skin.
That means it is not a drug that sends a signal to make more collagen like Juvelook does.
So you can set aside concerns about nodules caused by abnormal overgrowth.
This photo shows Juvelook particles, and they ‘induce’ collagen production.
However, some people come to us after being treated at another clinic saying they developed granules and asking us to dissolve them.
Because we cannot know what mixture was used or how it was injected at the previous clinic, it is better to contact the place where you received the procedure.
In most cases, however, they are naturally absorbed over time.
Once collagen is filled in this way, the first thing most people notice is a denser feel as the previously loose dermal layer becomes firmer again, along with improved dryness.
After that, the skin texture becomes smoother, and fine wrinkles—especially in thin-skin areas such as under the eyes and around the mouth—become less noticeable.
Clinical study results showing improvement. Pores and fine wrinkles decreased, right?
- Two ways to prevent Lituo nodules
Even if the principle is safe, discomfort can still occur depending on how the procedure is performed.
To fundamentally block the feeling of clumping that resembles a nodule,
the key is to inject evenly into the correct layer.

First, using a blunt-tip cannula reduces blood vessel damage while allowing the product to be spread very evenly and consistently between the lower dermis and the subcutaneous fat layer.
And because of the cannula’s characteristics, it is difficult to inject into the epidermis or the upper dermis.
This can help prevent the phenomenon of particles clumping together and appearing like nodules due to being placed too superficially.

Second, the skin under the eyes and around the mouth is very thin.
If these areas are injected too close to the skin surface, the particles may become visibly raised.
Because this treatment carries less nodule risk than other collagen boosters, it is often performed in the under-eye and mouth areas.
So when treating these areas, extra care is needed to ensure the product is not injected too superficially.

- Lituo cannula or manual injection: which should you choose?
“Doctor, but wouldn’t manual injection work better?” some people ask.
That is true. For people whose skin condition has dropped extremely and who need strong improvement, manual injection is a better choice.
I also recommend manual injection from the beginning for those patients.

However, one downside when performing the treatment is that people often find manual injection quite painful.
Since this ingredient is not just water, absorption happens more slowly and the swelling can last longer as well.
So for people who need to continue their daily life, the discomfort lasts longer.
That is why the treatment approach is decided according to skin condition.
In fact, for most people, the skin is in a condition where improvement can be achieved sufficiently with cannula alone.

If you are not sure which method you should choose, start with the cannula to minimize pain, and then observe the results.
If the degree of improvement seems somewhat lacking, combining it with manual injection is also an option.
Hongdae Lituo also has a longer-lasting effect when repeated several times.
That is why proper follow-up observation and chart management are important.
If you want to know how that management should be handled at a clinic, please read the post below.
- Frequently asked questions about Lituo (Q&A)
Q. Can I go back to my daily routine right after the procedure?
A. When performed with a cannula, there is less bruising and swelling, so daily life is barely affected on the same day.
Any needle marks usually go down within a few hours, and makeup is enough to cover them from the next day.
Q. Can I get it on the same day as other lifting procedures?
A. Yes, that is possible. However, the order matters.
If you are planning ultrasound lifting such as Ulthera, it is better from a safety standpoint to do Ulthera first.

Lituo key summary
- Hongdae Lituo directly replenishes collagen, so the risk of overgrowth (nodules) is almost nonexistent.
- The key is to use a cannula and inject evenly into a layer that is not too superficial.
- Depending on skin condition and pain level, it is good to choose between cannula and manual injection step by step.

Depending on how Hongdae Lituo is administered, you may experience unexpected side effects,
or you may be able to see the full effect.
The most important thing is not to have the procedure because it is trendy, but to receive an accurate diagnosis of whether it is needed for your skin.
I hope you get a proper diagnosis and receive the treatment safely.
Thank you. This was Dr. Jo Wonjin.
<The skin booster you need depends on your purpose>
When your skin is dry and sensitive: Rejuran
When you want to restore firm skin elasticity: Juvelook

