Seongdong-gu Dermatology: The Effects of Radiesse and Hilo Wave, and the Synergistic Effect When Used Together

Radiesse & Hilo Wave

Hello, this is Raon Dermatology in Seongdong-gu :)

As aging causes the skin’s internal components to diminish, elasticity decreases and fine irregularities naturally begin to appear across the face. These changes are a completely natural part of aging, but the concerns people actually feel are by no means small. Recently, interest has been growing in approaches that help the skin develop its own regenerative capacity. Among them, the combination of Radiesse and Hilo Wave is considered a representative pairing that can secure both skin tissue density and hydration at the same time :)

Radiesse & Hilo Wave

Radiesse

First, Radiesse is a self-collagen stimulating agent made by combining calcium hydroxylapatite (CaHA) and a CMC gel. CaHA particles are made of mineral materials similar to components found in the human body, so when injected into the body, they show biocompatibility without a sense of foreignness. If the CMC gel, which accounts for 70% of the total content, serves as a scaffold that shapes the area immediately after injection, the remaining 30% of fine particles become the key driving force that produces collagen within the skin!

Its goal is different from conventional methods that simply increase volume in a specific area for a short time. Rather than covering empty areas with external substances, it focuses on reconstructing the environment inside the dermis to induce healthy remodeling! Because the particle size is uniform and the viscoelasticity is excellent, it creates natural-looking results without clumping even in areas with frequent movement. It is highly useful in situations where tissue cohesiveness needs to be increased due to lip lines or an overall loss of elasticity.

Radiesse

Radiesse Mechanism of Action

It would be helpful to understand how Radiesse works within the skin, right? You can think of it as progressing in layers over time. In the initial stage after injection, the water-soluble carrier CMC gel immediately fills in sunken areas, producing a visual change that makes the volume look improved. The real changes begin after that, as the fine particles continuously stimulate fibroblasts and induce the synthesis of new collagen and elastin, the elastic fiber!

As time passes, the gel component that served as the carrier is safely absorbed into the body and disappears, while the newly formed self-tissue firmly fills that space. Because elasticity is maintained with one’s own tissue rather than depending on external substances, there is less sense of foreignness, and even facial expressions feel natural without awkwardness! The skin itself becomes thicker and goes through a process of recovering healthy density. This mechanism is not limited to a temporary effect, but makes a major contribution to maintaining a firm skin foundation over the long term :)

<Mechanism of Action of Radiesse>

• Immediately after injection: CMC gel component / immediate volume formation

• Mid-stage: CaHA particles / stimulation of fibroblasts

• Increased collagen & elastin production

• Long-term stage: Newly formed self-tissue / maintenance of a firm support structure

Radiesse Mechanism of Action

Hilo Wave

In the process of helping the skin regenerate, Hilo Wave takes on the role of rebuilding the environment. Hilo Wave is more than just a skin booster that simply adds moisture; it is a biostimulator that applies Dual HA Compound technology, which combines high-molecular-weight and low-molecular-weight hyaluronic acid. Here, non-crosslinked hyaluronic acid refers to a formulation in which high-purity molecules are precisely combined without chemical crosslinking agents! With a high concentration of 24 mg of hyaluronic acid per 1 cc, it offers much stronger moisture retention and longer-lasting effects than conventional products. Because it is a formulation based on pure hyaluronic acid that lowers concerns about nodules, it can be applied safely even to sensitive skin, which is one of its major features.

A high concentration of hyaluronic acid spreads smoothly between skin tissues and serves as the starting point for remodeling the entire dermal layer. In particular, the low-molecular-weight component penetrates quickly into the skin and plays a role in antioxidant action and improving the initial ECM environment! Meanwhile, the high-molecular-weight component acts like a moisture reservoir, maintaining long-term hydration and immediate volume. Thanks to this dual-structure action, it does not merely make the surface feel moist; it helps build the skin’s natural strength itself.

Hilo Wave

Hilo Wave Mechanism of Action

Hilo Wave focuses on its role as a biostimulator that helps the skin regain a healthy structure on its own, going beyond simple moisture replenishment. When a high concentration of hyaluronic acid reaching 24 mg per 1 cc enters the skin, the synthesis of types 1 and 3 collagen, which are essential to our body, becomes highly active. In particular, it excels at suppressing the activity of protein-degrading enzymes, which are the main cause of reduced skin elasticity, helping newly formed elastic components remain in the skin for longer.

In addition, because it uses the smooth fluidity of its own ingredients to densely fill the spaces between skin tissues, concerns about pain during the procedure or the formation of nodules that make the skin surface uneven can be reduced. As high-molecular-weight and low-molecular-weight hyaluronic acid are distributed across each skin layer, they increase the density of thinned skin and create a natural-looking volume! These changes help refine skin tone and restore a smoother texture, resulting in an overall healthier skin environment :)

<Mechanism of Action of Hilo Wave>

• Low-molecular-weight HA is rapidly absorbed / antioxidant action / environmental improvement

• High-molecular-weight HA acts as a reservoir / immediate volume / long-term hydration

• Fibroblast proliferation / stimulation of collagen synthesis / strengthening of skin structure

Hilo Wave Mechanism of Action

Synergistic Effect When Used Together

What happens if Radiesse and Hilo Wave are used together? You can think of it as combining the process of increasing elasticity within the skin and the process of creating a moisturizing environment that allows the ingredients to work well. While Radiesse stimulates collagen production within the skin to improve elasticity, Hilo Wave supplies high-concentration hyaluronic acid to richly hydrate the inside of the skin! In such a well-hydrated environment, the regenerative components of Radiesse can work more actively, increasing the speed and efficiency of cell regeneration.

In particular, Hilo Wave includes a function that suppresses newly formed collagen tissue from being easily broken down by enzymes. This helps the self-tissue created through Radiesse remain in the skin for a longer time, practically extending the duration of the treatment’s effects. Rather than simply providing temporary hydration, it improves the environment of the entire skin layer and helps maintain firmness for a long time! For those who want both elasticity and hydration that build up from within the skin while keeping discomfort low, it can be an effective option, right?

<Combined Effects of Radiesse & Hilo Wave>

• Improve elasticity + hydration at the same time

• Increase regeneration speed

• Extend maintenance duration

Synergistic Effect When Used Together

Radiesse & Hilo Wave