🌤 What if Doransamin Is Unavailable? A Summary of Alternative Medications Used for Melasma Treatment

Safe alternative medications recognized for bioequivalence, organized by a dermatologist

Hello, this is Yonsei Bomvit Dermatology.

The long-used ‘Doransamin Capsule’ for melasma treatment is occasionally out of stock, so we often get asked, “Can I take an alternative medication instead?”

Fortunately, several alternatives with the same ingredient as Doransamin Capsule (tranexamic acid 250 mg) are available.

Some of them have also been recognized by the Ministry of Food and Drug Safety as bioequivalent products (meaning their efficacy and absorption rate are the same).

In this post, we will compare six alternative medications with the same ingredient as Doransamin Capsule and explain in an easy way which one to choose.

Doransamin Capsule. Source: Korea Pharmaceutical Information Center

💊 List of alternative medicines for Doransamin

Product name	Manufacturer	Price	Bioequivalence recognized	Supply status
Doransamin Capsule	JEIL Pharmaceutical	80 KRW / 1 capsule	Reference product	In supply
Melanox Capsule	Theu Pharmaceutical	Non-covered	Bioequivalent product
Melasmin Capsule	Austin Pharmaceutical	Non-covered	Bioequivalent product	In supply
Melling GS Capsule	Genupharm	Non-covered		In supply
Tranecm Capsule	Mothers Pharmaceutical	Non-covered		In supply
Tramela Capsule	Dongkoo Bio & Pharma	Non-covered	Bioequivalent product
Transamin Capsule 250 mg	Macnulty Pharmaceutical	Non-covered		In supply

Source: Korea Pharmaceutical Information Center (as of 2025)

✅ What does bioequivalence recognition mean?

You may have heard the phrase “passed the bioequivalence test” before.

Simply put, it means that the Ministry of Food and Drug Safety has officially recognized that the product has the same absorption rate and effect as the original drug (Doransamin).

You can think of medicines with this certification as safe alternative medications with verified efficacy.

✅ Bioequivalent products:

• Melanox Capsule (Theu Pharmaceutical)

• Melasmin Capsule (Austin Pharmaceutical)

• Tramela Capsule (Dongkoo Bio & Pharma)

🙋 Which medicine should I choose?

• The most straightforward choice is Doransamin Capsule

• If it is unavailable, choose one of the bioequivalent alternatives to increase the likelihood of substitution

• The other medicines have the same dosage and directions for use (2 to 3 times a day)

📌 In closing

Consistency is the most important part of melasma treatment.

Even if Doransamin Capsule is temporarily unavailable, treatment can continue through alternative medications that have passed bioequivalence testing.

📍 Yonsei Bomvit Dermatology

📞 02-837-8275

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