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Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects

Hongdae Dermatology Skin Clinic 弘大美丽石医院 · ✦뷰티스톤의원 합정역✦ · December 11, 2025

​ Hello. This is Kim Jang-ju from Hwagok-dong Dermatology Clinic. ​ ​ Are you worried about dry skin and fine lines? ​ ​ Rejuran, known as the “salmon injection,” is attracting a l...

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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.

Clinic: Hongdae Dermatology Skin Clinic 弘大美丽石医院

Original post date: December 11, 2025

Translated at: April 20, 2026 at 1:48 PM

Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 1

Hello.

This is Kim Jang-ju from Hwagok-dong Dermatology Clinic.

Are you worried about dry skin and fine lines?

Rejuran, known as the “salmon injection,”

is attracting a lot of attention

for its skin regeneration and elasticity-improving effects.

But once you actually decide to get the procedure,

there are a lot of things people want to know.

When Rejuran’s effects appear.

How much pain there is.

Whether there are side effects.

From now on, I’ll explain everything

about Rejuran in detail.

Please read carefully,

and I hope this helps you make a wise choice.

How does Rejuran work?

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 2

The key ingredient in Rejuran is

polynucleotide (PN).

When DNA fragments extracted from salmon

are injected deep into the dermal layer of the skin,

fibroblasts are activated.

As a result, the production of collagen

and elastin increases.

Through this process,

the skin barrier is strengthened,

fine lines improve,

and elasticity is restored.

You can experience a comprehensive anti-aging effect

that also relieves dryness from within.

When do Rejuran’s effects start to show?

There are individual differences,

but most people begin to notice skin changes

about 2 to 4 weeks after the procedure.

The full Rejuran effect appears gradually

over 1 to 3 months.

This is because the regeneration process

inside the skin progresses slowly.

Rather than expecting dramatic changes all at once,

it is best to understand it as a process

of natural improvement over time.

(More detailed information below ▼)

How long do Rejuran’s effects last?

In general, the effects last

about 6 months to 1 year.

At first, it is recommended to receive

about 3 intensive treatments

at one-month intervals.

After that, maintenance treatments

every 3 to 4 months are common.

People who visit Hwagok-dong Dermatology Clinic

can also get more satisfying results

if they continue regular treatment at this interval.

Let me be honest about the pain

Compared with other skin boosters,

Rejuran tends to be somewhat painful.

Because it has to be injected

into the exact depth of the dermal layer,

irritation during the procedure

is unavoidable.

According to people who have had it before,

it is not unbearably painful,

but

they do clearly feel stinging

and pressure.

In particular, Rejuran has a high-viscosity formula,

so when it enters the skin,

more intense pain may be felt

momentarily.

What is the embossing effect?

The small bumpy raised texture

that appears on the skin surface immediately after the procedure

is called embossing.

This is a normal reaction that occurs

as the medication remains in the skin,

so there is no need to worry.

It usually disappears naturally

as it is absorbed over about 2 to 3 days.

How can pain be reduced?

If you are concerned about pain,

it can be eased with the following methods.

  1. Use of anesthetic cream

Applying it before the procedure

can significantly reduce pain.

  1. Choosing Rejuran HB

Because it contains hyaluronic acid

and anesthetic ingredients together,

it is much less painful than regular Rejuran.

  1. Using a microneedle device

Using an injection device with fine needles

can reduce pain even further.

When you consult at Hwagok-dong Dermatology Clinic,

if you ask in advance about pain-relief methods,

you can be guided to the best option

for you.

In conclusion, pain is

to some extent something you have to accept,

but there are various ways to reduce it,

and considering the results after the procedure,

many people judge it to be a level

that is sufficiently tolerable.

Side effects and precautions

Rejuran is known as a relatively safe procedure,

but that does not mean there is no possibility

of side effects at all.

Common reactions include bruising and swelling,

and in rare cases, inflammation or allergic reactions

may occur.

In most cases, recovery happens naturally

within a few days.

Accurate injection is the key

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 3

The success or failure of Rejuran treatment

depends on the medical staff’s skill.

It must be injected accurately into the dermal layer,

especially the thin 1 to 2 mm layer,

in order to see the proper Rejuran effect.

If injected too shallowly,

it stays only in the epidermis and the effect is minimal.

On the other hand, if it goes too deep,

it flows into the subcutaneous fat layer,

making it difficult to achieve the desired result.

Therefore, rather than relying only on the quality of the product,

it is important to check whether there are

experienced medical staff who can inject it precisely.

Also carefully look into whether the clinic

goes through sufficient consultation and diagnosis.

When choosing a dermatology clinic in Hwagok-dong,

I recommend checking whether there is medical staff

with abundant procedure experience,

and whether a systematic consultation system

is in place.

How can you maximize Rejuran’s effects?

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 4

For the best results,

aftercare is also important.

On the day of the procedure,

avoid washing your face and wearing makeup.

For one week,

avoid high-temperature environments

such as saunas and jjimjilbangs.

Keep up with

sufficient water intake

and strict sun protection.

If you manage it this way,

you can maintain the effects of Rejuran for longer.

At Hwagok-dong Dermatology Clinic,

we also provide detailed guidance on aftercare n after the procedure,

so if you have any questions,

please feel free to ask anytime.

Key points

To summarize the Rejuran information shared today:

  1. An anti-aging treatment using PN ingredients

that improve skin elasticity, skin texture,

and fine lines

  1. There is some pain, but various pain-relief methods exist

  2. Injecting at the correct depth is the key to effectiveness

If you have any additional questions

about Rejuran,

please leave them in the comments anytime.

I will answer them directly.

Thank you for reading.

This was Kim Jang-ju from Hwagok-dong Dermatology Clinic.

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 5

Hwagok-dong Dermatology Clinic: A Quick Overview of Rejuran Healer’s Effects and Side Effects image 6

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