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Rejuran Effects: When Do They Start? Maintenance Period and Number of Sessions Q&A

Hongdae Dermatology Skin Clinic 弘大美丽石医院 · ✦뷰티스톤의원 합정역✦ · April 16, 2026

Hello, This is Beauty's Doctor, Wi Youngjin. When consulting about Rejuran, I get a lot of surprisingly similar questions. “What kind of procedure is it?” “When do the effects show...

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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.

Clinic: Hongdae Dermatology Skin Clinic 弘大美丽石医院

Original post date: April 16, 2026

Translated at: April 19, 2026 at 1:55 PM

Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.

Rejuran Effects: When Do They Start? Maintenance Period and Number of Sessions Q&A image 1

Hello,

This is Beauty's Doctor, Wi Youngjin.

When consulting about Rejuran,

I get a lot of surprisingly similar questions.

“What kind of procedure is it?”

“When do the effects show?”

“Does it hurt?”

The reason these questions come up repeatedly is that

Rejuran is not a procedure like a simple filler

that changes things right away,

but a regenerative treatment that changes the skin

over time.

So today,

I’ll organize the questions that come up most often in the clinic,

focusing on the essentials

and making them a little easier to understand.

  1. What exactly is the Rejuran procedure?

Rejuran is a procedure that injects

PN (Polynucleotide),

a DNA precursor substance,

into the skin.

This ingredient

helps damaged tissue recover,

eases inflammatory responses,

and creates an environment in which the skin can regenerate on its own.

In other words, rather than filling the surface,

it is closer to a “regeneration-based treatment”

that improves the internal skin environment.

Originally, this ingredient was used for the treatment of burns and damaged skin,

and as it expanded into the cosmetic field,

it became established as the current Rejuran procedure.

Later, as Rejuran Healer became widely used,

different types such as Rejuran HB,

which added a hydrating function,

developed as well. 2. What skin concerns is it effective for?

Rejuran Effects: When Do They Start? Maintenance Period and Number of Sessions Q&A image 2

Depending on the product,

the focus of the effects differs slightly.

Rejuran Healer / Eye

→ Fine lines, skin regeneration focus

Rejuran HB

→ Regeneration + hydration

The important point here is not simply

whether it is “moisturizing or regenerative,”

but choosing the function needed according to the skin condition.

For example,

if your skin is dry and sensitive,

HB often feels more noticeable,

and if fine lines or loss of elasticity are the main concerns,

Healer is often more suitable. 3. Is it effective for fine lines, elasticity, skin texture, and scars?

Yes, it helps improve the skin overall.

Fine lines

Loss of elasticity

Rough skin texture

Acne scars

It plays a role in improving the basic skin environment for these concerns.

In particular, Rejuran does not directly stimulate collagen production itself;

rather, improvement happens naturally

as the skin goes through its own recovery process.

So the results are also characterized by

natural improvement rather than an overly dramatic change.

However,

if you want to place more emphasis on improving elasticity or scars,

combining it with Juvelook SB is often more effective

in terms of improving density. 4. When do the effects appear?

Rejuran Effects: When Do They Start? Maintenance Period and Number of Sessions Q&A image 3

Rather than immediately after the procedure,

you begin to notice changes in skin condition

after about one week.

At first,

dryness decreases

or the skin feels a little smoother,

and then

over 2 to 4 weeks,

skin texture, fine lines, and elasticity

show gradual improvement. 5. How long do the effects last?

On average,

about 2 months.

However, the important point is that

this procedure is not an effect that simply “goes away,”

but a method of gradually

and cumulatively improving skin condition.

So the more repeat treatments you have,

the more the skin condition itself

often becomes more stable. 6. How many sessions are appropriate?

Usually,

3 sessions at 1-month intervals

are recommended as the basic protocol.

The reason for this is that

the regenerative signal needs to be stimulated repeatedly

for the effects to settle in stably.

After that,

depending on the skin condition,

it continues as maintenance care.

In other words,

3 sessions are the “basic setup,”

and after that is for “maintaining condition.” 7. How painful is it?

Rejuran Effects: When Do They Start? Maintenance Period and Number of Sessions Q&A image 4

Rejuran HB contains lidocaine (an anesthetic ingredient),

so the pain is relatively mild.

With Rejuran Healer as well,

if numbing cream is applied sufficiently,

most people can tolerate it.

Rather than the pain itself,

the sensation varies more depending on the treatment area and the skin condition. 8. Does swelling or bruising occur after the procedure?

Because it is not a deeply injected procedure,

bruising is not very common.

However,

small dot-like marks at the injection site

or tiny pinpoint bleeding

may appear temporarily.

In most cases,

these reactions disappear naturally within 1 to 2 days. 9. When can I return to daily life?

Usually,

after a day or two,

makeup, going to work, appointments, and other daily activities

are possible without major issues.

However,

if you have an important event,

it is better to leave 2 to 3 days of buffer time. 10. Are there side effects or risks?

PN ingredients

are relatively safe.

All medications have the possibility of allergies,

but with Rejuran, the incidence is very low.

In most cases,

it ends with temporary swelling or redness,

and many people recover without any special treatment. 11. How is it different from other procedures / what combination works well?

Rejuran is a procedure that

creates a foundation for skin regeneration.

So when combined with Juvelook SB,

regeneration + structural improvement happen at the same time,

and the synergy is often good.

Compared with doing it alone,

a combined treatment plan often leads to a greater range of skin changes. 12. Which option suits each skin type?

The recommendation changes depending on the skin condition.

Acne / dry skin

→ Rejuran HB

Inflammation / fine lines

→ Rejuran Healer

Fine lines around the eyes / dark circles

→ Rejuran Eye

Applying them in this way,

separately according to the area,

is the best way to maximize results and satisfaction. 13. How is the price determined?

Rejuran is calculated

not based on cc,

but on a syringe / box basis.

Rejuran Healer

→ Usually 1 syringe of 2cc

Rejuran Eye / HB

→ Based on 1cc

The price varies depending on the treatment area, volume, and treatment scope.

Rejuran is not simply a procedure that fills the skin,

but a regenerative treatment that restores the skin itself.

Because it works by improving the skin over time

rather than producing immediate changes,

consistent treatment planning and

an individualized approach

are the key factors that determine the results.

Thank you for reading this long post.

This was Wi Youngjin.

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