Yeonsinnae Dermatology Skin Booster: Explaining the Difference Between ReTuo and Cellrdiem

A next-generation skin booster that is gaining attention

Human ADM (Human Acellular Dermis), is it really good?

Hello.

This is Beauty’s Doctor, Wi Young-jin.

Recently, there has been a sharp increase in inquiries

about a certain skin booster ingredient.

Patients visiting our Yeonsinnae dermatology clinic also

ask about it quite often.

When it was first released, I also took the position of

“let’s wait and see a little longer.”

But the situation is quite different now.

• About 1 year since launch

• Clinical cases accumulated at various hospitals

• Actual procedure data and patient responses stabilized

At this point, it is reasonable to classify it as

a next-generation skin booster.

It is an ingredient that is currently being applied in actual procedures at our Yeonsinnae dermatology clinic

after a demo.

Today, I’ll organize the most frequently mentioned topic these days:

👉 Human ADM (acellular allogeneic dermis)

And also what is commonly called the

“big three” products.

1. What is Human ADM (acellular allogeneic dermis)?

Just hearing the name

can make it sound very difficult.

But if you break down the structure,

it is easier to understand than you might think.

Terminology

✔ Allogenic dermis

→ Dermal tissue from the same species, that is, human skin tissue

✔ Acellular

→ Cells that cause immune reactions are removed

👉 In short,

it is “tissue in which the immune-response components have been removed from human skin,

leaving only the structure.”

In consultations at our Yeonsinnae dermatology clinic,

this is the key point I explain first.

Where does it come from?

This is something many people are curious about.

Allogeneic dermis is

👉 derived from donated human tissue.

(Medically, it is cadaver-based tissue)

But the important point is that

it is not used as-is.

What is removed

• Cells

• DNA

• Immune-triggering substances

All of these are completely removed.

What remains

• Collagen

• Elastin

• Glycosaminoglycans (GAGs)

In other words, only the key ECM components

that make up the skin structure remain.

Key point to understand

Existing skin boosters work by

stimulating the body to “make” collagen,

whereas

Human ADM works by

reinforcing the collagen structure itself.

This difference determines the

naturalness and stability of the treatment results.

This is also the part we emphasize most

at our Yeonsinnae dermatology clinic.

2. “Isn’t it a bit uncomfortable?” Is it safe?

This is the question we get the most.

Honestly,

I had the same concerns at first.

In fact, it is already an old technology

This ingredient is

not a new concept.

In plastic surgery, it has already been used for

• Skin reconstruction for burn patients

• Protective layers for implants

• Reinforcement of thin skin

👉 for decades.

The key to safety: AATB certification

This is the most important standard.

• Strict donor screening

• HIV / hepatitis B and C testing

• Syphilis testing

• Sterilization process

👉 Only tissue that passes these steps is used.

At our Yeonsinnae dermatology clinic as well,

we place importance on checking these standards when selecting products.

Legal management system

Another important point is that

👉 this is not simply a procedure,

👉 but a human tissue transplant concept.

Therefore,

• Consent forms are completed before the procedure

• Product numbers are registered with the national system

• A traceability management system is applied

👉 Safety management is very strict.

3. Advantages of the Human ADM skin booster

Why has it established itself in the market so quickly?

Structure of existing skin boosters

Juvelook / Sculptra / Radiesse

👉 Common point

👉 Inflammation response → collagen production

Differences in Human ADM

👉 No inflammation induction

👉 Direct structural reinforcement

Summary of advantages

• Minimal inflammatory response

• High biocompatibility

• Less foreign-body sensation

• Very natural results

👉 In particular,

👉 “I want to improve without it looking like I had something done”

For this kind of need,

it is a high-choice option even at our Yeonsinnae dermatology clinic.

Expected effects

• Skin texture improvement

• Skin tone improvement

• Increased elasticity

• Reduction of fine wrinkles

• Pore improvement

• Improvement of inner dryness

• Reduction of redness

👉 Overall upgrade in skin quality

4. Disadvantages and limitations

Every procedure has limitations.

1️⃣ Psychological barrier

The fact that it is “human tissue”

2️⃣ Embossing

Temporary unevenness

• Occurs when injected too superficially

• In most cases, it disappears within several days to several weeks

3️⃣ Volume limitations

Some absorption occurs

No immediate volume like filler

4️⃣ Price

600,000 to 800,000 KRW range

At our Yeonsinnae dermatology clinic as well,

we explain this thoroughly during consultation.

5. Comparison of the Human ADM big three

Each product has a different position.

① ReTuo

• Manufactured by a major domestic human tissue company

• The most clinical data

• Particle size about 100 µm

👉 Stability standard model

② Cellrdiem

• Particle size about 75 µm (finer)

• Higher ECM content

👉 Features

• Reduced pain

• Excellent spreading

• Faster collagen response

③ Juvocell

• Supercritical CO₂ process

• No chemical use

👉 Advantages

• High purity

• Less clumping

👉 Disadvantages

• No AATB certification

• Lower ECM content

6. Who is it suitable for?

This is the most important part.

Recommended for

• Thinner skin

• Increased fine wrinkles

• Those who want natural improvement

• Those who feel burdened by procedures that look obvious

Not recommended

• Those who need immediate volume

• Those whose main goal is strong lifting

For these cases,

fillers / lifting devices are more suitable.

At our Yeonsinnae dermatology clinic as well,

we determine whether to proceed based on these criteria.

Human ADM skin booster is

👉 not about stimulation,

👉 but about reinforcing structure.

✔ Natural change

✔ High safety

✔ Improvement without looking obvious

👉 However,

👉 volume / lifting effects are limited

In the end,

if you want skin that improves naturally,

it is a very good option.

Thank you for reading this long post.

This was Wi Young-jin.