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Rejuran Side Effects: What Reactions May Occur After the Procedure?

Hongdae Dermatology Skin Clinic 弘大美丽石医院 · ✦뷰티스닥터 합정역✦ · July 13, 2026

Hello. I’m Ha-won Kim from Beauty’s Doctor. ​ ​ When searching for Rejuran side effects, the first images you often see are of red, swollen skin or bruising. ​ ​ That is why many p...

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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.

Clinic: Hongdae Dermatology Skin Clinic 弘大美丽石医院

Original post date: July 13, 2026

Translated at: August 17, 2026 at 2:52 PM

Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 1

Hello.

I’m Ha-won Kim from Beauty’s Doctor.

When searching for Rejuran side effects,

the first images you often see are of red, swollen skin or bruising.

That is why many people worry before the procedure,

asking, “Is it supposed to swell this much?”

However, not every reaction that appears immediately after the procedure

indicates an abnormal reaction.

Rejuran is a procedure that uses needles

to inject its ingredients into the skin.

Therefore, it is important to understand the difference between reactions that occur during the injection process

and reactions that require further attention.

Rejuran What kind of procedure is it?

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 2

Rejuran is a skin booster that injects PN (polynucleotide) ingredients

into the dermal layer.

Rather than immediately filling in volume like a filler,

it is used to induce a response in the skin tissue.

Since injections may be administered closely together

across multiple areas of the face,

reactions caused by the injection process itself

are also fairly common, apart from those caused by the ingredients.

The appearance immediately after the procedure

may vary slightly depending on the injection depth and location,

as well as the thickness of the skin.

Reactions that are easy to mistake for Rejuran side effects

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 3

The most common reactions immediately after the procedure

are redness and mild swelling.

Because the needle enters the skin multiple times,

temporary reactions may occur.

Bruising may also develop,

and it may appear more noticeable around the eyes and mouth,

where the skin is thinner.

As the Rejuran ingredients settle into the skin,

raised, embossed-like marks may appear.

They may be surprising at first,

but they often gradually fade over time.

You may also feel stinging

or warmth immediately after the procedure.

Many people worry that these are Rejuran side effects,

but such reactions may be included among the effects explained

to patients during the early post-procedure period.

Still, it is important to observe whether the swelling and pain

decrease over time.

Rare but important reactions that require attention

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 4

In rare cases, an allergic reaction may occur,

or the injection site may feel firm to the touch.

Because Rejuran uses salmon-derived ingredients,

you should inform the provider in advance if you have a salmon allergy.

Since this procedure uses needles,

there is also a possibility of inflammation or infection.

If the swelling and redness continue to worsen,

or if severe pain and warmth persist

and pus or discharge develops,

it is better to contact the medical institution where you received the procedure

rather than making a judgment on your own.

In such cases, the current condition needs to be examined directly

to determine whether it is a Rejuran side effect.

If one side is unusually swollen

or the skin looks a different color than usual,

it is also better to have it checked rather than simply waiting.

How long does recovery take?

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 5

Redness and mild swelling

often fade within a few days.

Bruising may remain a little longer,

depending on the condition of your skin.

The raised, embossed-like marks

also often gradually flatten over time.

Recovery time may vary depending on the thickness of the skin

and the injection site.

Reactions may remain visible longer in areas with thin skin,

such as around the eyes, than in other areas.

If you have an important event coming up,

it is better to leave some time before the event rather than scheduling the procedure immediately beforehand.

Rejuran is sometimes administered over multiple sessions

rather than completed in a single treatment,

so it is helpful to know that similar reactions

may recur after each procedure.

After the procedure, aftercare is also important

On the day of the procedure,

avoid repeatedly touching the injection sites.

It is best to temporarily avoid environments with high heat,

such as saunas and heated bathhouses.

Alcohol and strenuous exercise

may also make swelling and redness last longer.

While your skin is sensitive,

reduce the use of highly irritating cosmetics,

and continue basic skin care,

including sun protection.

When washing your face,

it is better to care for your skin gently

rather than rubbing it forcefully.

What do we check during a consultation?

During the consultation, we check your skin condition

along with whether you have recently received any procedures.

Any medications you are taking

and your history of allergies are also important considerations.

If you have a salmon allergy

or have experienced an abnormal reaction after an injection procedure,

it is best to mention it in advance during the consultation.

If there is inflammation or a wound at the treatment site,

the current condition must be assessed first.

After checking your current skin condition,

you will be advised on whether the procedure is appropriate

and how it should be carried out.

Not every procedure

is necessary for every person.

It is important to determine whether it is suitable

after considering your current skin condition

and individual characteristics together.

Frequently asked questions

Rejuran Side Effects: What Reactions May Occur After the Procedure? image 6

Q. Is it common to feel warmth after receiving Rejuran?

Warmth or stinging

may occur immediately after the procedure.

In most cases,

these sensations gradually ease over time.

However, if the warmth and pain become more severe,

it is best to consult a medical professional.

Q. How long do the raised, embossed-like marks last?

Although it varies from person to person,

they often gradually fade over time.

The length of time they remain visible

may vary depending on the injection site and skin thickness.

Q. When should I have Rejuran side effects checked again?

If the swelling and pain continue to worsen,

or if warmth persists

and pus or changes in skin color appear,

it is best to have your condition checked

at the medical institution where you received the procedure.

Thank you for reading this long post.

This was Ha-won Kim.

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Rejuran Side Effects: What Reactions May Occur After the Procedure? image 8

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