Does Omokgyo Rejuran Really Improve Your Skin? Let’s Look at the Research

Does Omokgyo Rejuran really improve your skin?

Let’s look at the research

Hello.

I’m Kim Jin-hyun, Chief Director of U&I Clinic Mokdong.

"If I get Rejuran, will my skin really get better?

Is it like filler, where it adds volume?"

These are questions I hear very often during consultations these days.

Especially people who searched for Omokgyo Rejuran and came in often

have already seen some information through social media or reviews.

But once I explain it, many people say they’re still confused about whether it’s filler, Botox, or some other type of treatment.

In fact, Rejuran is not a treatment that creates dramatic visible changes.

Instead, it is closer to a treatment that gradually restores the skin’s own health.

So today, rather than just talking about ads or reviews,

I’d like to look at how the key ingredient in Rejuran is actually described in research papers.

If you read for about 3 minutes, you’ll be able to judge a little more objectively how Rejuran works,

and for whom it may be a meaningful treatment.

Table of Contents
1. Rejuran: Why is it so popular?​2. The skin regeneration effects of polynucleotide described in research​3. So, is Rejuran right for me?

1. Rejuran: Why is it so popular?

Omokgyo Rejuran

First, let’s organize what kind of treatment Rejuran is.

This is the part many people find confusing.

Is it a treatment that fills in volume like filler,

or one that smooths wrinkles like Botox?

To start with the conclusion:

Rejuran is neither of those.

Rejuran is a skin booster treatment whose main ingredient is polynucleotide (PN) extracted from salmon.

When this ingredient is injected into the dermis layer of the skin,

it helps damaged skin cells recover

and works by stimulating collagen production.

Let me explain with a simple analogy. Filler is closer to filling an empty room with furniture.

Because it fills the space right away,

the change shows up quickly.

Rejuran, on the other hand, is closer to repairing the walls and floor of the room itself.

Because it works by strengthening the structure,

the changes appear more gradually, but it acts in a way that improves the skin’s overall condition.

At this point, the key ingredient is polynucleotide.

It is a long nucleic acid molecule extracted from salmon DNA, and because it is similar to human DNA structure, it is known to have high biocompatibility.

In addition, antioxidant and anti-inflammatory effects have also been reported, suggesting that it may help improve the skin’s overall environment.

Because of these characteristics, it matches well with the recent beauty trend of natural-looking skin improvement,

and interest has rapidly increased among both younger people and middle-aged adults.

However, one important question remains.

Does it really have a skin regeneration effect?

So in the next section, we’ll look at how polynucleotide is described in actual research papers.

2. The skin regeneration effects of polynucleotide described in research

Omokgyo Rejuran

Consensus report on the use of PN-HPT™ (polynucleotides

highly purified technology) in aesthetic medicine

In 2021, the Journal of Cosmetic Dermatology published an expert consensus paper on the use of polynucleotides.

This study was conducted with experts from the Italian Society of Aesthetic Medicine,

and it organized the mechanism of action and treatment protocol of polynucleotides.

According to the paper, polynucleotides are highly purified DNA molecules extracted from salmon gonads, and because of their long DNA chain structure, they have viscoelastic properties.

This viscoelasticity can create a temporary filling effect, but more importantly, it stimulates fibroblasts.

When fibroblasts are activated, collagen and elastin production increases, which may help restore the skin’s self-regeneration ability.

The paper also mentions that external factors such as ultraviolet rays, smoking, and stress

can increase reactive oxygen species and reduce antioxidant substances, and that PN may have a protective effect against this oxidative stress.

One interesting part of the paper is the priming concept it presents.

It suggests that if PN is injected first,

the skin tissue may become more responsive to subsequent treatments.

In other words, it may play a role in preparing the skin environment in advance before treatments such as lasers or fillers.

Clinical studies have also reported certain improvement results.

In a study of 143 patients, a tendency toward improved skin elasticity and hydration was confirmed.

In addition, in patients in their 30s, pores and skin thickness improved, and in patients in their 40s, improvements in skin tone and wrinkles were observed.

However, the study also notes a limitation: since it is based on expert consensus, its level of evidence differs from that of large randomized controlled trials.

3. So, is Rejuran right for me?

Omokgyo Rejuran

So, when applying this research to actual treatment, what should you consider?

First, the most important point is the number of sessions.

Most of the protocols presented in the paper are based on 3 to 4 treatments at 14- to 21-day intervals.

In other words, rather than a treatment that ends after one session,

it is more realistic to view it as an approach that gradually improves the skin condition through a set cycle.

There was also a lot of opinion that the best results appear when it is used together with other treatments rather than on its own.

For example, combining it with laser treatment or using a formulation combined with hyaluronic acid.

So Rejuran may be suitable in situations like these:

When skin texture looks rough or fine wrinkles have increased

When skin hydration and elasticity have decreased and the overall complexion looks dull

When skin conditioning is needed to enhance the effects of other treatments

On the other hand, it is not a treatment that immediately solves deep wrinkles or severe sagging.

In such cases, it may be more realistic to use Rejuran as a basic skin-improvement step and plan it together with other lifting treatments or lasers.

So far, I’ve explained Rejuran’s mechanism and the effects of PN described in research for those of you looking into Omokgyo Rejuran.

However, to expect good results, it is important to consider the proper number of sessions, the interval between them, and a plan that matches the skin condition.

With that emphasized, I’ll end here.

This has been Kim Jin-hyun, Chief Director of U&I Clinic Mokdong. ^^

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