When Does Rejuran Work? Changes from Day 3 to 3 Months, a Dermatology Director’s Complete Summary

Hello.

Only as much as needed, become prettier!

I’m Director Lee Mira, head doctor of Vanni Skin Clinic.

Rejuran Healer is something everyone says is good. In a word, it can be described as a premium nutrient for the skin. It is true that it is a versatile skin booster that can improve elasticity, soften fine lines, and relieve inner dryness, but it is by no means a cure-all.

That is why there are people who feel that Rejuran Healer has no effect even after the time when its effects should have appeared has passed. This stems from misunderstandings about Rejuran’s improvement effects.

Rejuran Healer is among the more expensive skin boosters, and above all, it comes with tremendous pain. If you endured even the severe pain and still did not get the results you expected... there is nothing more disappointing. (Of course, our clinic has five anesthesia options, so you can receive the procedure relatively comfortably.)

So in today’s column, I’ll explain the changes that happen inside the skin by stage after the Rejuran procedure, when the effects appear, and also the skin concerns that are difficult to improve with Rejuran versus those for which it is effective.

It’s not too late to decide after reading this article carefully from the start. Let’s get right into the main point.

When does Rejuran start working?

Rejuran Healer is not a procedure that instantly makes a dramatic change in the skin; rather, it helps the skin recover on its own over time. When PN (polynucleotide) ingredients are injected into the skin, they activate fibroblasts, induce collagen and elastin production, and strengthen the skin barrier.

These changes do not happen overnight, and the effects appear gradually after a certain period of time following the procedure.

So let me explain, stage by stage, when you can start feeling the effects after Rejuran Healer.

1. Immediately after the procedure (~within 3 days): embossing & initial response

When PN ingredients are directly injected into the dermis, the skin shows an immediate response, and the representative sign is embossing (raised swelling). This is a normal phenomenon that occurs as the PN ingredients settle between the skin tissues, and it usually disappears naturally within 2 to 3 days. (However, depending on the amount of medication and metabolic process, it can last up to 7 days.)

In addition, needle marks may remain at the treatment site, and tiny red dots or bruising may appear.

This is a reaction that occurs as the skin accepts the PN ingredients, and it usually disappears naturally within a week.

You may also feel a pulling sensation in the skin, but this is a phenomenon that appears as regenerative reactions begin inside the skin, so there is no need to worry.

| 📌 Characteristics of the period from immediately after the procedure to within 3 days - Embossing appears at the injection site (disappears within 2 to 3 days) - Needle marks, slight swelling, and bruising may occur - The skin may feel tight (reaction begins in the dermis) |

2. 1 to 2 weeks after the procedure: skin hydration & improvement in inner dryness

About a week after the procedure, the PN ingredients inside the skin interact with skin tissue and skin regeneration gradually begins. From this time on, you can feel an increase in skin moisture and an improvement in inner dryness.

PN ingredients play a role in increasing the skin tissue’s ability to retain moisture. Because they boost the skin’s natural moisturizing ability, people who normally suffer from severe dryness may notice their skin becoming more hydrated from this stage. In addition, the skin texture may gradually become smoother, and a mild anti-inflammatory effect can also be expected. If you have skin that tends to break out often, you may feel that breakouts calm down thanks to PN’s anti-inflammatory action.

| 📌 Characteristics of 1 to 2 weeks after the procedure - Increased moisture inside the skin → improvement in inner dryness - Skin texture becomes smoother and feels more hydrated - Mild inflammation is reduced (fewer breakouts) |

3. 3 to 4 weeks after the procedure: collagen synthesis activation & increased skin elasticity

Three to four weeks after the procedure, fibroblasts inside the skin become activated and collagen and elastin production begins in earnest. During this process, you may experience increased skin elasticity and a reduction in fine lines.

Collagen and elastin are key components that support the skin and are important factors in determining skin elasticity. The PN ingredients in Rejuran Healer help skin cells produce more collagen.

As time passes, the skin may feel firmer, and fine lines may gradually become less noticeable. In addition, as the skin barrier strengthens, the skin becomes less sensitive to external irritation, which is another major change during this period.

| 📌 Characteristics of 3 to 4 weeks after the procedure - Collagen production is activated → skin elasticity increases - Fine lines gradually soften - Skin barrier strengthens → increased resistance to external irritation |

4. 1 to 3 months after the procedure: maximum effect & maintenance of skin condition

One to three months after the procedure, the effects of Rejuran Healer are maximized in earnest.

Collagen and elastin produced inside the skin make the skin tissue firmer, and the strengthened skin barrier helps moisture remain consistently maintained.

During this period, the skin texture becomes smoother, and you can experience a noticeable softening of fine lines. The overall skin tone also becomes more even, breakouts decrease, and the overall condition of the skin improves significantly. This is when you can truly understand why people keep saying, “There’s a reason Rejuran is Rejuran.”

| 📌 Characteristics of 1 to 3 months after the procedure - Collagen and elastin production is maximized → skin elasticity reaches its peak - Fine lines noticeably soften and skin texture becomes smoother - Skin barrier strengthens → moisture is maintained and overall skin condition improves |

How to maintain Rejuran’s effects for longer

Rejuran Healer can be effective even with a single treatment, but consistent care is the most important thing. Since the skin regeneration process takes time, receiving three consecutive treatments at one-month intervals is the most effective, and after that, maintenance treatments once every 6 months to 1 year are recommended.

Rejuran Healer is not a cure-all.

As mentioned in the introduction, Rejuran Healer is indeed a versatile skin booster, but it is not a cure-all that can solve every skin concern.

In particular, if your main concern is enlarged pores or if you are hoping for improvement in pigmentation (melasma, blemishes), Rejuran Healer alone may not be enough. On the other hand, if your skin is dry or you are concerned about fine lines, it is a treatment that can deliver good results.

1. If you are worried about enlarged pores

Rejuran Healer can help improve skin elasticity, but if pores that were originally round have stretched into an oval shape, or if pores have widened due to excessive sebum secretion, you also need treatments such as Potenza for sebum control.

In other words, if you want to reduce pores, it is difficult to achieve sufficient improvement with Rejuran Healer alone, and you need to undergo treatments that address the cause of the pore enlargement.

2. If you want to improve pigmentation such as melasma and blemishes

After receiving Rejuran Healer, the skin becomes clearer and healthier-looking. However, this is a change that comes from strengthened skin barriers and increased moisture content, not an effect that removes pigmentation such as melasma or blemishes.

Pigmentation conditions such as melasma, blemishes, and freckles occur when melanin pigment is overproduced inside the skin. Since Rejuran does not directly destroy melanin or reduce pigment, it is better to combine it with toning laser treatment if you are hoping for pigmentation improvement.

Skin concerns for which Rejuran Healer can be highly effective

1. If you have thin skin

Rejuran Healer makes the dermis healthier and thicker, so it is especially effective if you have thin skin.

As we age, collagen and elastin in the dermis decrease, making the skin thinner. If you receive Rejuran Healer consistently, collagen and elastin are produced, making the skin thicker, which not only slows aging but may also make you look much younger than your actual age.

2. If you are concerned about fine lines

Fine lines appear for reasons such as lack of moisture in the skin, reduced elasticity, and decreased collagen. Rejuran Healer promotes collagen synthesis and strengthens the skin barrier, so if you have more fine lines than expected for your age or if your skin is thin and fine lines show easily, it can be an effective choice.

In particular, severe dryness can make fine lines more noticeable. With Rejuran, the amount of moisture inside the skin increases, and over time, collagen is produced, so you can expect fine lines to gradually soften.

However, if deep wrinkles or reduced elasticity are also present, Rejuran alone may have limitations. In such cases, combining it with a skin elasticity-improving treatment such as Olligeo can maximize the effect.

Many people look up information online when considering a procedure. But among the information there are also many exaggerated statements and inaccurate claims. It is only natural for patients to believe them and develop expectations, and it is by no means the patient’s fault.

Rejuran Healer is also one of the procedures that is widely misunderstood. Because it is so well known for “skin regeneration” and “improving elasticity,” it is described as if it were a universal solution that solves all skin problems, but no treatment can solve every skin concern at once.

Rejuran Healer is effective for improving inner dryness, softening fine lines, and increasing skin elasticity, but to address enlarged pores or pigmentation concerns, it needs to be combined with appropriate other treatments.

It is important to accurately understand your skin condition and choose the procedure that is right for you, isn’t it?

And! There is one more big misunderstanding about Rejuran Healer. It is the claim that if there is no embossing, the procedure was done incorrectly. The column below explains the meaning of embossing during Rejuran treatment and the conditions that actually determine the results, so if you are considering Rejuran, please be sure to check the article below as well. 😊

[The correlation between Rejuran embossing and its effects, the real conditions that determine the result]

https://blog.naver.com/rush_724/223756464945