"in and of itself" is an English expression used when focusing on a thing, phenomenon, or fact itself.
Literally, it means "by itself" or "intrinsically," and it is often used when talking about the subject alone before considering its essential characteristics or context.
For example, it can be used to say that a certain result is not bad "by itself," but may be problematic in the overall context.
In U.S. academic conferences and scholarly discussions, it appears very often when evaluating data or interpreting papers.

Five example sentences
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The results of this study, in and of itself, may not be impressive.
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The treatment, in and of itself, isn’t novel.
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The data, in and of itself, is not sufficient to draw a definitive conclusion.
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This symptom, in and of itself, is not dangerous.
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The side effect, in and of itself, isn’t severe, but it may pose long-term risks.