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Hongdae Dermatology Skin Clinic 弘大美丽石医院 · ✦뷰티스닥터 합정역✦ · June 24, 2026
Hello. I’m Youngjin Wi from Beauty Doctor. When skin texture, fine lines, or dryness become a concern, you may often come across the name Rejuran while looking into options and thi...
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This page is an English translation of a Korean Naver Blog archive entry. For exact wording and source context, verify against the Korean archive original and the original Naver post.
Clinic: Hongdae Dermatology Skin Clinic 弘大美丽石医院
Original post date: June 24, 2026
Translated at: August 17, 2026 at 4:22 PM
Medical note: This translation does not guarantee medical accuracy or suitability for treatment decisions.
Hello.
I’m Youngjin Wi from Beauty Doctor.
When skin texture, fine lines, or dryness become a concern, you may often come across the name Rejuran while looking into options and thinking, “Should I try a hydration injection?”
Because it is administered by injection, it is easy to think of it as a treatment that immediately replenishes moisture, like hyaluronic acid.
However, Rejuran is difficult to view as simply an injection that replenishes moisture.
The key is its PN ingredient.
The key ingredient in Rejuran is PN, or polynucleotide.
PN is known as an ingredient extracted and purified from salmon-derived DNA.
Rejuran is described as an injectable treatment based on PN that is intended to support the environment within the skin.
Pharmaresearch materials also describe Rejuran as a medical device intended for the temporary improvement of facial wrinkles using PN.
Hyaluronic acid injections tend to attract moisture or supplement volume.
In contrast, Rejuran is better understood as supporting the environment within the skin, rather than creating immediate volume at the injection site.
Therefore, Rejuran may look similar to a “hydration injection,” but its mechanism should be viewed differently.
PN is short for Polynucleotide.
In skin treatments, it is often described as an ingredient that supports responses related to tissue repair within the skin.
However, it is important not to make definitive statements such as “the skin regenerates immediately” or “collagen is produced.”
The response can vary depending on an individual’s skin condition, the injection site and depth, and their history of previous treatments.
If you have heard the term “salmon injection,” you may have come across PDRN as well.
Both PN and PDRN are often described as salmon-derived DNA ingredients.
However, they are not the same concept.
PN
→ A relatively long-chain structure
PDRN
→ Relatively short DNA fragments
Rejuran
→ Known to be based on PN
Because the names are similar, they can easily be confused. During a consultation, it is better to distinguish which ingredient is being used.
PDRN is described as relatively short DNA fragments, while PN is described as a longer-chain structure.
Thus, although both share the characteristic of being “salmon-derived ingredients,” their treatment purposes and product characteristics can be viewed differently.
In other words, rather than grouping them together by saying, “They all come from salmon, so they are the same injection,” it is better to confirm whether the ingredient is PN or PDRN.
Rejuran is a treatment intended to support the environment within the skin.
Therefore, treatment plans are often developed while monitoring the skin’s condition, rather than making a definitive judgment based on a single treatment.
The approach may vary depending on skin thickness, dryness, fine lines, sensitivity, and previous treatment history.
During a consultation, it is more important to first assess the skin’s current condition than to focus on a fixed number of treatments.
Rejuran is often administered by injecting small amounts into the skin at multiple points.
As a result, the injection sites may appear slightly raised.
This is commonly referred to as embossing.
Embossing is one possible temporary response after injection, but its severity and duration may vary from person to person.
Before consulting about Rejuran, it is helpful to confirm the following:
Whether your main concern is skin texture
Whether dryness is your primary concern
Whether fine lines are bothering you
Whether you have a history of fillers or skin boosters
Whether you have a salmon or seafood allergy
Whether you have been informed about the possibility of bruising, swelling, and embossing
In particular, responses to injectable treatments can vary depending on the skin’s condition and the injection depth.
Therefore, it is important to determine whether the treatment is appropriate for your skin, rather than simply choosing it because it is popular.
Rejuran may be suitable in some cases, while another skin booster or laser treatment may be more appropriate in others.
The treatment approach may vary depending on whether the skin is thin, how severe the dryness is, the amount of fine lines, and whether inflammation or sensitivity is present.
Therefore, during a consultation, it is important to consider the skin’s current condition and the intended purpose of treatment before focusing on the product name.
Q. Is Rejuran the same as a hydration injection?
They are difficult to view as exactly the same concept.
Hydration injections are often understood as treatments focused on moisturization or supplementing moisture, while Rejuran is described as a treatment based on PN that supports the environment within the skin.
Q. What is the difference between PN and PDRN?
Both are often described as salmon-derived DNA ingredients, but their structures and uses are understood differently.
PN can be distinguished as a relatively long-chain structure, while PDRN consists of relatively short DNA fragments.
Q. Is one Rejuran treatment enough?
It depends on the individual’s condition.
The treatment plan may vary depending on skin thickness, fine lines, dryness, and previous treatment history.
Rather than following a predetermined number of treatments, it is better to make a decision suited to your current condition after a medical consultation.
Q. Why does embossing occur?
As the ingredient is injected into the skin at multiple points, the injection sites may temporarily appear raised.
The severity and duration may vary from person to person.
Q. Should I avoid it if I have allergies?
If you have a salmon or seafood allergy, be sure to mention it in advance during your consultation.
Your allergy history, skin sensitivity, and previous treatment history are important information to check before treatment.
Rejuran can be understood as an injectable treatment based on PN that supports the environment within the skin, rather than simply an injection that replenishes moisture.
However, it is not suitable in the same way for every skin type.
It is better to consider your skin texture, dryness, fine lines, sensitivity, and previous treatment history together, and first determine whether this is the treatment your current condition requires.
Thank you for reading this long post.
This was Youngjin Wi.
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